Hyperalgesia and sensitization of dorsal horn neurons following activation of NK-1 receptors in the rostral ventromedial medulla
نویسندگان
چکیده
منابع مشابه
NK-1 receptors modulate the excitability of ON cells in the rostral ventromedial medulla.
The role of neurokinin-1 (NK-1) receptors in the rostral ventromedial medulla (RVM) was studied using extracellular single-unit recording combined with microiontophoresis. In rats, on- and off-type neurons were identified using noxious heat or mechanical stimuli applied to the tail. Responses evoked by iontophoretic application of N-methyl-d-aspartate (NMDA) were determined before and after int...
متن کاملDifferential modulation of neurons in the rostral ventromedial medulla by neurokinin-1 receptors.
The rostral ventromedial medulla (RVM) is part of descending circuitry that modulates nociceptive processing at the level of the spinal cord. RVM output can facilitate pain transmission under certain conditions such as inflammation, and thereby contribute to hyperalgesia. Evidence suggests that substance P and activation of neurokinin-1 (NK-1) receptors in the RVM are involved in descending fac...
متن کاملActivation of mu-opioid receptors inhibits synaptic inputs to spinally projecting rostral ventromedial medulla neurons.
The rostral ventromedial medulla (RVM) is a major locus for the descending control of nociception and opioid analgesia. However, it is not clear how opioids affect synaptic inputs to RVM neurons. In this study, we determined the effect of mu-opioid receptor activation on excitatory and inhibitory synaptic transmission in spinally projecting RVM neurons. RVM neurons were retrogradely labeled wit...
متن کاملActivation of μ Opioid Receptors Inhibits Synaptic Inputs to Spinally Projecting Rostral Ventromedial Medulla Neurons
The rostral ventromedial medulla (RVM) is a major locus for the descending control of nociception and opioid analgesia. However, it is not clear how opioids affect synaptic inputs to RVM neurons. In this study, we determined the effect of μ opioid receptor activation on excitatory and inhibitory synaptic transmission in spi nally projecting RVM neurons. RVM neurons were retrogradely labeled wit...
متن کاملSensitization of pain-modulating neurons in the rostral ventromedial medulla after peripheral nerve injury.
Nerve injury can lead to mechanical hypersensitivity in both humans and animal models, such that innocuous touch produces pain. Recent functional studies have demonstrated a critical role for descending pain-facilitating influences from the rostral ventromedial medulla (RVM) in neuropathic pain, but the underlying mechanisms and properties of the relevant neurons within the RVM are essentially ...
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ژورنال
عنوان ژورنال: Journal of Neurophysiology
سال: 2017
ISSN: 0022-3077,1522-1598
DOI: 10.1152/jn.00478.2017